Topical antibacterial antiacne agent

Some non-antibiotic antibacterial agents can be applied as a gel or cream topically. These act on the bacterial proliferation in the skin and therefore on the development ofacne. Benzoyl peroxide is one of these topical antibacterial antiacne agents.

How do the topical antibacterial, antiacne agents act?

These medicines work against acne by reducing colonisation of the skin by Propionibacterium acnes. Benzoyl peroxide also reduces free fatty acids which have an irritating comedogenic effect. On the other hand this topical medicine has no proven action on sebaceous secretions.

Do they have contraindications or precautions?

Benzoyl peroxide can cause dry skin. It can also discolour clothing and hair. In addition, some patients can suffer allergic reactions, although fortunately these are rare. The gel applications appear to be better tolerated.

Sources:

• Merck Manuel, 4^th edition
• Dermatology therapeutics from the René Touraine Foundation, accessed on 29 June 2011