The prime-boost (primer-booster) is a vaccination strategy administered in several stages which presents the same antigen through different vectors.
One of the stages is called " DNA " and involves injecting a fragment of DNA which carries a gene coding for the antigenic protein. The body can then translate the DNA into the antigen and produce the corresponding antibodies.
Another stage is called "protein ". It is the antigen in this stage, which is administered directly in the form of the protein.
The DNA stage generally precedes the protein stage.
The prime-boost vaccination method appears to be more effective than the conventional single stage vaccination strategy, particularly in vaccinations against the influenza virus.
The prime-boost is a vaccination strategy involving several heterogeneous phases. © Grook Da Oger / Licence Creative Commons