Macrolide

The macrolides are antibiotics prescribed particularly for upper respiratory tract infection (Streptococcal A pharyngitis), lower respiratory tract or skin infections. They are mostly administered orally.

How do the macrolides work?

The macrolides act within the cells, specifically on the bacterial ribosomes, the organelles which are responsible particularly for the synthesis of proteins. In this way they kill the bacterium.

Do they have contraindications or precautions?

The main side effects seen with these medicines are allergic and skin reactions: erythema, urticaria, pruritus and occasionally, severe skin reactions. Gastro-intestinal problems (nausea, vomiting, diarrhoea, abdominal pain) and liver disorders can also be seen. Macrolides are not recommended in patients with liver impairment.

Sources:

• Merck Manual – 4^th edition
• Transparency forms, Anti-infectious medicines in community-acquired diseases, Afssaps, 2004