The incretins are hormones secreted by the gastro-intestinal tract. They are released when we eat food and trigger secretion of insulin by the pancreas. The incretin modulators act by blocking an enzyme which degrades the incretins – DPP4 - or by promoting secretion of incretin GLP1 (for glucagon-like peptide 1), which in turn stimulates insulin production. These treatments also delay gastric emptying. They can therefore cause a reduction in appetite and weight loss.
The incretin modulators can cause nausea, particularly when the treatment is started. They are also contraindicated in severe renal failure.
The incretins are hormones secreted by the gastro-intestinal tract. © Phovoir