The incretin modulators are injectable treatments used for type 2 diabetes. These antidiabetic agents belong to the insulin secretagogue family. They are the latest of the antidiabetic agents.
How do the incretin modulators act?
The incretins are hormones secreted by the gastro-intestinal tract. They are released when we eat food and trigger secretion of insulin by the pancreas. The incretin modulators act by blocking an enzyme which degrades the incretins – DPP4 - or by promoting secretion of incretin GLP1 (for glucagon-like peptide 1), which in turn stimulates insulin production. These treatments also delay gastric emptying. They can therefore cause a reduction in appetite and weight loss.
Do they have contraindications or precautions?
The incretin modulators can cause nausea, particularly when the treatment is started. They are also contraindicated in severe renal failure.
- Merck Manual – 4th edition ;
- Association française des diabétiques (French Diabetic Association), website accessed on 26 April 2011
The incretins are hormones secreted by the gastro-intestinal tract. © Phovoir
Incretin modulators - 1 Photo