Fosfomycin is also called fosfonomycin or phosphomycin and is a bactericidal antibiotic produced by different species of bacteria belonging to the Streptomycesgenus. It belongs to the family of phosphonic acids. It can be used as a first line single dose for the treatment of the great majority of uncomplicated lower urinary infections in young women.
How does fosfomycin work?
Fosfomycin acts by inhibiting the synthesis of the bacterial wall. The antibiotic inhibits an enzyme which is essential for the production of N-acetylmuraminic acid, one of the essential constituents of the bacterial wall. As fosfomycin is relatively poorly absorbed by the digestive tract, it is usually administered parenterally.
Contraindications or precautions?
Because it is administered as a single dose, it is well tolerated. However, it is contraindicated in severe renal impairment.
- Merck Manual – 4th edition
- Transparency forms, Anti-infectious medicines in community-acquired diseases, Afssaps, 2004
The fosfomycins are used to treat many urinary infections. © Phovoir