Direct renin inhibitor
The direct renin inhibitors are the most recent class of medicines marketed since 2009 to treat hypertension. The direct renin inhibitors produce a large fall in blood pressure .
How do the direct renin inhibitors work?
Just like the angiotensin converting enzyme inhibitors (ACEIs) and angiotensin 2 receptor antagonists, the direct renin inhibitors block the renin-angiotensin-aldosterone system. They are an alternative treatment or can be used in combination with renin-angiotensin-aldosterone system inhibitors, calcium blockers and diuretics.
Do they have contraindications or precautions?
This class of medicines is tolerated similarly to the angiotensin 2 receptor antagonist class. The commonest side effects are back pain, episodes of constipation, diarrhea, asthenia, headaches and sore throats.
- Merck Manual – 4th edition
- Comité français de lutte contre l'hypertension artérielle (French hypertension committee), website accessed on 17 June 2011
- Pharmacorama, website accessed on 17 June 2011
New treatments for hypertension © Phovoir
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