Diabetic sulphonamides

Also called sulphonylureas, diabetic sulphonamides (SU) are oral treatments used in the management of type 2 diabetes. These anti-diabetic agents belong to the insulin secretagogue family.

How do they work?

After insulin, the diabetic sulphonamides are the longest standing medicines used in treating diabetes. They stimulate insulin secretion in the beta cells of the pancreas. They are categorised as secretagogues and therefore act directly by increasing the amount of circulating insulin in the blood.

Does they have any contraindications or precautions?

While they may cause hypoglycaemia, diabetic sulphonamides can also promote weight gain of 2 to 5 kilos. They are also contraindicated in renal impairment, liver impairment and in pregnancy.

Source: Merck Manual – 4^th edition