The antiparkinsonian agents are medicines used to treat Parkinson's Disease and its consequences. There are now five main categories of these.
The different antiparkinsonian agents
- Levodopa (L-dopa) is the most commonly used antiparkinsonian medicine . This is converted into synthetic dopamine in the patient's body. It does, however, cause many central nervous system complications: motor fluctuations, involuntary movements and drowsiness.
- The dopamine agonists act directly on the dopamine receptors. These synthetic compounds are administered in association with L-dopa and mimic the action of dopamine.
- MAO-B (monoamine oxidase B) inhibitors reduce the degradation of dopamine.
- Catechol-O-methyltransferase (COMT) inhibitors have the same effect as the MAO-B inhibitors. They therefore increase the effectiveness of dopamine.
- The anticholinergics are being used increasingly less.
- Interview with Jean-Philippe Brandel, neurologist at the Léopold Bellan Hospital, Paris, on www.infopatients-lundbeck.fr , 7 July 2011
- MyPDinfo.com, 7 July 2011
There are five categories of medicines to treat Parkinson's disease. © Phovoir
Antiparkinsonian - 1 Photo